Jessica Santollo, Ph.D.
Jessica Santollo, Ph.D.
Summary of Research Interests:
My research is focused on understanding how gonadal hormones, specifically estrogen, contribute to sex differences in ingestive behaviors. Estrogens reduce food, water, and salt intakes in females but the exact mechanisms by which this occurs is unknown. Current research projects focus on (1) identifying the estrogen receptor subtypes and populations which underlie these behavioral changes, (2) investigating estrogen receptor specific effects on cell signaling pathways downstream of the angiotensin type 1 receptor, (3) investigate the role of aging in estradiol’s anti-dipsogenic and anti-natriorexigenic effects, and (4) identifying and exploring sex differences in the renin-angiotensin system.
- Santollo, J. & Daniels, D. (in press) Multiple estrogen receptor subtypes influence ingestive behavior in female rodents. Physiology and Behavior.
- Santollo, J. & Daniels, D. (2015) Activation of G protein coupled estrogen receptor (GPER-1) decreases fluid intake in female rats. Hormones and Behavior, 73, 39-46.
- Santollo, J. & Daniels, D. (2015) Control of fluid intake by estradiol in the female rat: role of the hypothalamus. Frontiers in Systems Neuroscience, 9.
- Santollo, J., Whalen, P.J., Speth R.C., Clark, S.D., & Daniels, D. (2014) Properly timed exposure to central angiotensin II prevents behavioral sensitization and changes in angiotensin receptor expression. American Journal of Physiology, 307, R1396-R1404.
- Marshall, A., Santollo, J., Corteville, Lutz, T.A., & Daniels, D. (2014) Roux-en-Y gastric bypass does not affect daily water intake or the drinking response to dipsogenic stimuli in rats. American Journal of Physiology, 307, R114-R120.
- Halpern, C.H., Keating, J.G., Wolf, J.A., Santollo, J., Daniels, D. & Bale, T.L. (2013) Amelioration of binge eating by nucleus accumbens shell deep brain stimulation in mice involves D2 receptor modulation. The Journal of Neuroscience, 33, 7122-7129.
- Santollo, J., Marshall, A. & Daniels, D. (2013) Activation of membrane-associated estrogen receptors decreases food and water intake in OVX rats. Endocrinology, 154, 320-329.
- Santollo, J., Yao, D., Neal-Perry, G.S. & Etgen, A.M. (2012) Middle-aged female rats retain sensitivity to the anorexigenic effect of exogenous estradiol. Behavioral Brain Research, 232, 159-164.