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Derek Daniels, Ph.D.

Ph.D., University of Pennsylvania
335 Hochstetter
(716) 645-0264
Lab web page
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Summary of Research Interests

Research in my laboratory focuses on the neural mechanisms that regulate ingestive behaviors such as food, water, and salt intake. These behaviors are critical for the maintenance of body fluid, cardiovascular, and energy homeostasis. Specific areas of interest include the neural circuits that contribute to these behaviors and the intracellular events that occur at various nodes within the circuits. At the present time, the two main areas of focus include: 1) testing for overlap in peptide systems that affect both feeding and drinking behaviors; and 2) determining the behavioral relevance of individual intracellular signaling pathways, especially as they relate to sensitization and desensitization.

Representative Publications

  • Santollo, J. and D. Daniels. (2015) Control of fluid intake by estradiol in the female rat: role of the hypothalamus. Frontiers in Systems Neuroscience, 9, 25.
  • McKay, N.J., D.L. Galante, and D. Daniels. (2014) Fluid and food intakes engage separable elements of the endogenous glucagon-like peptide-1 system in rats. Journal of Neuroscience, 34(49):16417-23.
  • Santollo, J., P.E. Whalen, R.C. Speth, and D. Daniels. (2014) Properly timed exposure to central angiotensin II prevents behavioral sensitization and changes in angiotensin receptor expression. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 307(12):R1396-404.
  • Santollo, J, A. Marshall, and D. Daniels. (2013) Activation of membrane-associated estrogen receptors decreases food and water intake in ovariectomized rats. Endocrinology, 154(1):320-329.
  • McKay, N.J. and D. Daniels. (2013) Glucagon-like peptide-1 receptor agonist administration suppresses both water and saline intake in rats. Journal of Neuroendocrinology,25:929-938.
  • Marshall, A. and D. Daniels. (2012) Evaluating the potential for rostral diffusion in the cerebral ventricles using angiotensin II-induced drinking in rats. Brain Research, 1486: 62-67.
  • Vento, P.J. and D. Daniels. (2012) Mitogen-activated protein kinase is required for the behavioural desensitization that occurs after repeated injections of angiotensin II. Experimental Physiology, 97(12):1305-1314.
  • Vento, P. and D. Daniels (2010). Repeated administration of angiotensin II reduces its dipsogenic effects without affecting saline intake. Experimental Physiology, 95(6): 736-745.
  • Daniels, D., D.K. Yee, L.F. Faulconbridge, and S.J. Fluharty (2005) Divergent behavioral roles of angiotensin receptor intracellular signaling cascades. Endocrinology,146 (12):5552-60.