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Michael A. Bozarth, Ph.D.

Associate Professor
Ph.D., Concordia University
B-77 Park Hall
(716) 645-0267

Professional Websites:
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Summary of Research Interests

My empirical research has involved primarily investigating the biological basis of appetitive motivation and reward processes with special attention to addictive agents such as the psychomotor stimulants (e.g., amphetamine, cocaine, methamphetamine) and the opioids (e.g., heroin, morphine, oxycodone). Other interests involve the neuropsychopharmacology of catecholamine systems (e.g., dopamine) and their relationship to general motivational theory and specific applications in biological psychiatry. My more recent work is largely directed to applying what I’ve learned over the past 35+ years studying addictive behavior and the neuroscience of addiction; specifically, my work now involves (1) facilitating addiction technology transfer, (2) development of more rational drug-regulation policies, and (3) application of harm-reduction strategies. Another active line of investigation involves the study of terrorism and the deployment of better counter-terrorism strategies. This last endeavor uses primarily a social cognition approach to better understand the terrorist’s mindset and to help develop more effective predictive algorithms for potential adversarial events.

Representative Publications

  • Bozarth, M.A. (1983). Opiate reward mechanisms mapped by intracranial self-administration. In J.E. Smith and J.D. Lane (Eds.), Neurobiology of opiate reward processes (pp. 331-359). Amsterdam: Elsevier/North Holland Biomedical Press.
  • Bozarth, M.A., & Wise, R.A. (1984). Anatomically distinct opiate receptor fields mediate reward and physical dependence. Science, 244, 516-517.
  • Bozarth, M.A., & Wise, R.A. (1985). Toxicity associated with long-term intravenous heroin and cocaine self-administration in the rat. Journal of the American Medical Association, 254, 81-83.
  • Bozarth, M.A. (1986). Neural basis of psychomotor stimulant and opiate reward: Evidence suggesting the involvement of a common dopaminergic system. Behavioural Brain Research, 22, 107-116.
  • Bozarth, M.A. (1987). (Ed.). Methods of assessing the reinforcing properties of abused drugs. New York: Springer-Verlag. (658 pp.)
  • Wise, R.A., & Bozarth, M.A. (1987). A psychomotor stimulant theory of addiction. Psychological Review, 94, 469-492.
  • Bozarth, M.A. (1990). Drug addiction as a psychobiological process. In D.M. Warburton (Ed.), Addiction controversies (pp. 112-134 + refs). London: Harwood Academic Publishers.
  • Bozarth, M.A. (1991). The mesolimbic dopamine system as a model brain reward system. In P. Willner and J. Scheel-Krüger (Eds.), The mesolimbic dopamine system: From motivation to action (pp. 301-330). London: John Wiley & Sons.
  • Bozarth, M.A. (1994). Pleasure systems in the brain. In D.M. Warburton (ed.), Pleasure: The politics and the reality (pp. 5-14 + refs). New York: John Wiley & Sons.
  • Bozarth, M.A., Pudiak, C.M., & KuoLee, R. (1998). Effect of chronic nicotine on brain stimulation reward: I. Effect of daily injections. Behavioural Brain Research, 96, 185-188.
  • Bozarth, M.A., Pudiak, C.M., & KuoLee, R. (1998). Effect of chronic nicotine on brain stimulation reward: II. Effect of escalating doses. Behavioural Brain Research, 96, 189-194.
  • Pudiak, C.M., & Bozarth, M.A. (2002). Nitric oxide synthesis inhibition attenuates intravenous cocaine self-administration in rats. Progress in Neuro-psychopharmacology & Biological Psychiatry, 26, 189-196.
  • Pudiak, C.M., & Bozarth, M.A. (2013). Effect of Post-Trial L-NAME Administration on Cocaine Sensitization. International Journal of Neuroscience, in press (posted online 03 April 2013).